TBPH

TBPH is a brominated flame retardant. TBPH enhances hepatic steatosis, inflammation, and fibrosis in mice with nonalcoholic steatohepatitis (NASH) . TBPH induces dysregulation of phospholipid metabolism, reducing cardiolipin (CL) and phosphatidylserine (PS) levels. TBPH leads to impaired endoplasmic reticulum-mitochondria (ER-Mito) contacts, subsequently causing mitochondrial dysfunction. TBPH induces lung injury through an inflammatory response mediated by mitochondria-derived ds-DNA. TBPH can be used to study the role of MFN2-mediated ER-mitochondria contacts in lipid metabolism homeostasis[1][2].

Product Specifications

CAS Number

[26040-51-7]

UNSPSC

12352005

Hazard Statement

H227, H315, H319, H335

Target

ClpP; Cytochrome P450; Eukaryotic Initiation Factor (eIF) ; HSP; Interleukin Related; LDLR; Mitochondrial Metabolism; TNF Receptor

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Purity

95.26

Solubility

DMSO : ≥ 175 mg/mL

Smiles

O=C(OCC(CC)CCCC)C1=C(Br)C(Br)=C(Br)C(Br)=C1C(OCC(CC)CCCC)=O

Molecular Formula

C24H34Br4O4

Molecular Weight

706.14

Precautions

H227, H315, H319, H335

References & Citations

[1]Zhou Y, Li B, Zhao J, Ren X, Guo Y, Yang L, Han J, Wu L, Zhou B. Bis (2-Ethylhexyl) -2,3,4,5-Tetrabromophthalate Promotes NASH Progression through Disrupting Endoplasmic Reticulum-Mitochondria Contacts. Environ Sci Technol. 2025 Jul 22;59 (28) :14302-14313. |[2]Xing B, et al. TBPH-induced lung injury is induced by mitochondrial-derived ds-DNA-mediated inflammatory response. Ecotoxicol Environ Saf. 2024 Nov 1;286:117200.