5-Iodouracil

5-Iodouracil (Compound 4b) is an irreversible dihydropyrimidine dehydrogenase (DPD) inhibitor (IC50=0.22 μM) . 5-Iodouracil is promising for research of DPD-overexpressing solid tumors like non-small cell lung cancer (NSCLC) [1].

Product Specifications

CAS Number

[696-07-1]

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H315, H319, H335

Target

Dihydropyrimidine Dehydrogenase (DPD)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Purity

99.95

Smiles

O=C1NC=C(I)C(=O)N1

Molecular Formula

C4H3IN2O2

Molecular Weight

237.98

Precautions

H302+H312+H332, H315, H319, H335

References & Citations

[1]Hattori K, et al. Design and synthesis of the tumor-activated prodrug of dihydropyrimidine dehydrogenase (DPD) inhibitor, RO0094889 for combination therapy with capecitabine. Bioorg Med Chem Lett. 2003 Mar 10;13 (5) :867-72.