ART5803
ART5803 is a humanized IgG1 monoclonal antibody inhibitor targeting NMDAR. ART5803 binds to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD) with a high affinity. ART5803 blocks NMDAR internalization induced by pathogenic autoantibodies and restores cell-surface NMDAR expression and functions. ART5803 reverses behavioral abnormalities and NMDAR expression in marmoset disease models. ABT-147 can be used to study anti-NMDAR encephalitis[1].
Product Specifications
CAS Number
[3058434-76-4]
UNSPSC
12352203
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
References & Citations
[1]Kanno A, et al. Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis. Nat Commun. 2025 Jun 17;16 (1) :5292.
Shipping Conditions
Room temperature
Storage Conditions
-80°C
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported
Isoform
NMDA Receptor
Curated Selection
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