JMV 170

JMV 170, a CCK derivative, is a selective CCK-B agonist. JMV 170 binds to the CCK-B receptor with a 10-fold higher affinity than to the CCK-A receptor. JMV 170 shows contractile effects on pig smooth muscle cells with an EC50 of 9 pmol/L[1].

Product Specifications

CAS Number

[117829-60-4]

UNSPSC

12352209

Target

Cholecystokinin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

C([C@@H](C(N[C@H](C(N[C@H](C(NCCC1=CC=CC=C1)=O)CC(O)=O)=O)CCCC)=O)NC(CNC([C@@H](NC([C@H](CC2=CC=C(OS(=O)(=O)O)C=C2)NC(OC(C)(C)C)=O)=O)CCCC)=O)=O)C=3C=4C(NC3)=CC=CC4

Molecular Formula

C51H68N8O14S

Molecular Weight

1049.21

References & Citations

[1]Gue M, et al. Neuropeptide Y and sigma ligand (JO 1784) suppress stress-induced colonic motor disturbances in rats through sigma and cholecystokinin receptors. J Pharmacol Exp Ther. 1992 Jun;261 (3) :850-5.|[2]Botella A, et al. Cholecystokinin and gastrin induce cell contraction in pig ileum by interacting with different receptor subtypes. Gastroenterology. 1992 Mar;102 (3) :779-86.