D15
D15, a peptide with 15 aa segment of dynamin, is an AMPAR endocytosis inhibitor. D15 blocks the interaction of dynamin with amphiphysin 1 and 2. D15 significantly increases AMPAR excitatory postsynaptic potential (EPSC) amplitude of medium spiny neurons (MSNs) in Sapap3 KO mice. D15 can be used for neuropsychiatric disorder research[1].
Product Specifications
CAS Number
[251939-41-0]
Product Name Alternative
Dynamin II (828–842)
UNSPSC
12352209
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(N[C@@H](C(C)C)C(N2[C@@H](CCC2)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N3[C@@H](CCC3)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N4[C@@H](CCC4)C(N5[C@@H](CCC5)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]6N(CCC6)C([C@@H]7CCCN7)=O
Molecular Formula
C69H111N23O19
Molecular Weight
1566.76
References & Citations
[1]Wan Y, et al. Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses. J Neurosci. 2011 Nov 16;31 (46) :16685-91.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
Launched
Isoform
AMPA Receptor
Curated Selection
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