VMAPRTLFL

VMAPRTLFL is a 9-mer peptide derived from the signal peptide of HLA-G and can serve as a peptide ligand for HLA-E. VMAPRTLFL plays a crucial role in regulating the functions of adaptive natural killer (NK) cells. Specifically, VMAPRTLFL enriches FcεRγ- adaptive NK cells, upregulates the expression of CD25, and enhances their proliferative activity, antibody-dependent cellular cytotoxicity (ADCC), and IFN-γ release. VMAPRTLFL can be used in research related to human cytomegalovirus (HCMV) infection, transplant rejection, and pregnancy immunity[1].

Product Specifications

CAS Number

[202657-61-2]

UNSPSC

12352209

Target

MHC

Related Pathways

Immunology/Inflammation

Field of Research

Infection; Inflammation/Immunology

Smiles

CC(C)[C@H](N)C(N[C@@H](CCSC)C(N[C@@H](C)C(N1[C@@H](CCC1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C49H82N12O11S

Molecular Weight

1047.31

References & Citations

[1]Rölle A, et al. Distinct HLA-E Peptide Complexes Modify Antibody-Driven Effector Functions of Adaptive NK Cells. Cell Rep. 2018 Aug 21;24 (8) :1967-1976.e4.