β4-TAT

β4-TAT is a kind of β-sheet peptide foldamer. β4-TAT is composed of two parts: the β4 sequence (derived from the β-sheet fragment of the RRM domain of fused in sarcoma (FUS) ) and the TAT sequence (a nuclear localization signal peptide that helps the entire peptide penetrate the nuclear membrane) . β4-TAT influences FUS aggregation by targeting its RNA recognition motifs (RRM) . β4-TAT effectively induces FUS aggregation within cells, leading to the death of cancer cells. β4-TAT can be used for the study of FUS[1].

Product Specifications

CAS Number

[2780353-11-7]

Product Name Alternative

FUS (364-369) -TAT

UNSPSC

12352209

Target

Others

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C)C(N[C@@H](CC2=CC=C(C=C2)O)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)N

Molecular Formula

C96H169N39O21

Molecular Weight

2205.62

References & Citations

[1]Wang MD, et al. Homologous Peptide Foldamer Promotes FUS Aggregation and Triggers Cancer Cell Death. J Am Chem Soc. 2024 Oct 23;146 (42) :28669-28676.