TI-16

TI-16 is a peptide that targets β-amyloid (Aβ) protein. TI-16 can cross the blood-brain barrier. TI-16 can increase the concentration of intracellular free CaM, thereby restoring calcium ion homeostasis and reducing Aβ toxicity. TI-16 can reduce the deposition of Aβ in the brain, improve neuronal pathology, inhibit cell apoptosis, and improve cognitive function in mice. TI-16 is commonly used in the study of Alzheimer's disease[1].

Product Specifications

CAS Number

[659739-64-7]

UNSPSC

12352209

Target

Amyloid-β; Apoptosis; CaMK

Related Pathways

Apoptosis; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(NCC(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC5=CC=CC=C5)N

Molecular Formula

C72H102N24O21

Molecular Weight

1639.73

References & Citations

[1]Su J, et al. A calmodulin-derived peptide TI-16 inhibits Alzheimer's disease progression by decreasing -Aβ burden and restoring calcium dyshomeostasis. Bioorg Chem. 2025 Jun 15;160:108502.