LDKA

LDKA is a helical membrane-active antibacterial peptide. LDKA forms an ensemble of pores of different sizes. LDKA has antibacterial activity against both Gram-positive (S. aureus) and Gram-negative (E. coli and P. aeruginosa) bacteria in a nutrient-rich medium, with MICs in the 10-70 μM range[1].

Product Specifications

CAS Number

[2243297-90-5]

UNSPSC

12352209

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](C)C(NCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

Molecular Formula

C68H124N16O17

Molecular Weight

1437.81

References & Citations

[1]Chen CH, et al. Simulation-Guided Rational de Novo Design of a Small Pore-Forming Antimicrobial Peptide. J Am Chem Soc. 2019 Mar 27;141 (12) :4839-4848.