Leucocin A

Leucocin A (LeuA), a 37-amino acid peptide, is a class II bacteriocin without Lanthionine (HY-135113) . Leucocin A has potent anti-bacterial activity against gram-positive bacteria, such as Leuconostoc paramesenteroides and Lactobacillus sake with MICs of 69 and 39 nM, respectively. Leucocin A can be used for infectious diseases research[1].

Product Specifications

Product Name Alternative

LeuA

UNSPSC

12352209

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC2=CC=C(C=C2)O)C(NCC(N[C@@H](CC(N)=O)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC4=CNC5=CC=CC=C45)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CO)C(N[C@@H](C)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CC7=CNC=N7)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](CC(N)=O)C(NCC(NCC(N[C@@H](CC(N)=O)C(NCC(N[C@@H](CC8=CC=CC=C8)C(N[C@@H](CC9=CNC%10=CC=CC=C9%10)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC%11=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(NC%11)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N

Molecular Formula

C174H246N52O50S2

Molecular Weight

3930.26

References & Citations

[1]Fleury Y, et al. Covalent structure, synthesis, and structure-function studies of mesentericin Y 105 (37), a defensive peptide from gram-positive bacteria Leuconostoc mesenteroides. J Biol Chem. 1996 Jun 14;271 (24) :14421-9.