MGF24

MGF24 is a modified protease-resistant MGF derivative. MGF24 protects dopaminergic neurons from 6-Hydroxydopamine (6-OHDA) (HY-113028) -induced apoptosis by inducing Heme oxygenase-1 (HO-1) . MGF24 activates PKC-ε, which in turn activates Nrf2, up-regulating HO-1. MGF24 has neuroprotective activity and reduces myocardial infarct size in sheep models of myocardial ischemia. MGF24 can be used for neurological diseases like stroke, nerve injury and amyotrophic lateral sclerosis research[1].

Product Specifications

CAS Number

[1611488-66-4]

UNSPSC

12352209

Target

Apoptosis; Drug Derivative; Heme Oxygenase (HO) ; Keap1-Nrf2; PKC

Related Pathways

Apoptosis; Epigenetics; Metabolic Enzyme/Protease; NF-κB; Others; TGF-beta/Smad

Field of Research

Neurological Disease

Smiles

O=C(N[C@@H](CCC(N)=O)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC5=CC=C(C=C5)O)N

Molecular Formula

C121H195N41O39

Molecular Weight

2848.09

References & Citations

[1]Quesada A, et al. C-terminal mechano-growth factor induces heme oxygenase-1-mediated neuroprotection of SH-SY5Y cells via the protein kinase Cϵ/Nrf2 pathway. J Neurosci Res. 2011 Mar;89 (3) :394-405.