Periplanetasin-4

Periplanetasin-4 is an antimicrobial peptide that can be derived from the American cockroach (Periplaneta americana) . Periplanetasin-4 reduces cell rounding and apoptosis. Periplanetasin-4 blocks Clostridium difficile toxin A-induced ROS production and the activation of downstream p38 MAPK and p21. Periplanetasin-4 significantly increases mitochondrial calcium level, reduces DPH fluorescence intensity and vacuolar dysfunction in Candida albicans ATCC 90028 cells. Periplanetasin-4 significantly ameliorates toxin A-induced mucosal damage in the mouse gut. Periplanetasin-4 can be used for the study of colitis[1][2].

Product Specifications

CAS Number

[2206807-06-7]

UNSPSC

12352209

Target

Apoptosis; Bacterial; Caspase; p38 MAPK; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Smiles

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC2=CC=C(C=C2)O)C(NCC(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CS)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(NCC(N4[C@@H](CCC4)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N

Molecular Formula

C70H110N20O15S

Molecular Weight

1503.81

References & Citations

[1]Yoon IN, et al. The American cockroach peptide periplanetasin-4 inhibits Clostridium difficile toxin A-induced cell toxicities and inflammatory responses in the mouse gut. J Pept Sci. 2017 Nov;23 (11) :833-839.|[2]Lee H, et al. Periplanetasin-4, a novel antimicrobial peptide from the cockroach, inhibits communications between mitochondria and vacuoles. Biochem J. 2019 Apr 26;476 (8) :1267-1284.