Link N peptide

Link N peptide is a proteoglycan aggregates activator in the extracellular matrix. Link N peptide can selectively activate the p38 mitogen-activated protein kinase (MAPK) pathway to promote the expression of type I and II collagens in human intervertebral disc cells. Link N peptide is promising for research of intervertebral disc degeneration-related diseases[1][2].

Product Specifications

CAS Number

[197295-74-2]

UNSPSC

12352209

Target

P38 MAPK

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Others

Purity

99.62

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

OC(C=C1)=CC=C1C[C@@H](C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC2=CN=CN2)=O)=O)=O)=O)=O)CC3=CN=CN3)=O)=O)=O)=O)NC([C@H](CC(N)=O)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC4=CN=CN4)=O)=O)=O)=O)=O

Molecular Formula

C81H120N26O29

Molecular Weight

1921.98

References & Citations

[1]Petit A, et al. Effect of synthetic link N peptide on the expression of type I and type II collagens in human intervertebral disc cells. Tissue Eng Part A. 2011 Apr;17 (7-8) :899-904.|[2]AlGarni N, et al. Short Link N Stimulates Intervertebral Disc Repair in a Novel Long-Term Organ Culture Model that Includes the Bony Vertebrae. Tissue Eng Part A. 2016 Nov;22 (21-22) :1252-1257.