Corza6 (TFA)

Corza6 TFA is a potent and selective human voltage-gated proton channel (hHv1) peptide inhibitor. Corza6 TFA binds to the external voltage sensor domain (VSD) loop in hHv1 with a Kd of ~1 nM at the natural, hyperpolarized resting membrane potential (RMP) of mammalian cells. Corza6 TFA allows capacitation in sperm and permits sustained reactive oxygen species (ROS) production in white blood cells (WBCs) [1].

Product Specifications

UNSPSC

12352209

Target

Proton Pump; Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB

Field of Research

Metabolic Disease

Purity

95.53

Solubility

H2O : 100 mg/mL

Smiles

O=C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@H]2CC3=CNC=N3)=O)=O)=O)=O)NC4=O)C(N[C@@H]([C@@H](C)CC)C(N5[C@@H](CCC5)C(N[C@@H](CO)C(NCC(N[C@@H](CCC(N)=O)C(N6[C@@H](CCC6)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CCCCN)C(N[C@@H](CC7=CNC8=CC=CC=C78)C(N[C@@H](C(C)C)C(N[C@@H](CC9=CC=CC=C9)C(N[C@@H](CC%10=CC=CC=C%10)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CC%11=CC=CC=C%11)C(N[C@H]%12CCSC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC2=O)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@H]4CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC%13=CNC%14=CC=CC=C%13%14)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)NC%12=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N.OC(C(F)(F)F)=O.[x]

Molecular Formula

C203H293N55O61S7.xC2HF3O2

Molecular Weight

4704.29 (free base)

References & Citations

[1]Ruiming Zhao, et al. Role of human Hv1 channels in sperm capacitation and white blood cell respiratory burst established by a designed peptide inhibitor. Proc Natl Acad Sci U S A. 2018 Dec 11;115 (50) :E11847-E11856.