(RXR) 4XB (TFA)

(RXR) 4XB TFA is a cell-penetrating peptide, that binds the phosphorodiamidate morpholino oligomers (PMOs), forms peptide-conjugated PMOs (PPMOs), and improves the delivery of PMO into bacterial cells. (RXR) 4XB TFA-PMO conjugate prevents the formation of biofilms, inhibits Pseudomonas aeruginosa with MIC50 of 0.5 to 16 μM, and reduces the bacterial burden in mouse acute pneumonia models[1].

Product Specifications

UNSPSC

12352209

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Purity

96.56

Smiles

N=C(NCCC[C@@H](C(NCCCCCC(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(NCCCCCC(NCCC(O)=O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)N)N.OC(C(F)(F)F)=O.[x]

Molecular Formula

C81H158N38O15.xC2HF3O2

Molecular Weight

1904.37 (free base)

References & Citations

[1]Howard JJ, et al., Inhibition of Pseudomonas aeruginosa by Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers. Antimicrob Agents Chemother. 2017 Mar 24;61 (4) :e01938-16.