Pepstatin (Standard)

Pepstatin (Standard) is the analytical standard of Pepstatin. This product is intended for research and analytical applications. Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease[1][2].

Product Specifications

CAS Number

[26305-03-3]

Product Name Alternative

Pepstatin A (Standard)

UNSPSC

12352209

Target

Autophagy; HIV Protease; Reference Standards

Related Pathways

Anti-infection; Autophagy; Metabolic Enzyme/Protease; Others

Field of Research

Infection; Inflammation/Immunology

Smiles

CC(C[C@H](NC([C@@H](NC([C@@H](NC(CC(C)C)=O)C(C)C)=O)C(C)C)=O)[C@@H](O)CC(N[C@@H](C)C(N[C@@H](CC(C)C)[C@@H](O)CC(O)=O)=O)=O)C

Molecular Formula

C34H63N5O9

Molecular Weight

685.89

References & Citations

[1]Umezawa H, et al. Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo) . 1970 May;23 (5) :259-62.|[2]Seelmeier S, et al. Human immunodeficiency virus has an aspartic-type protease that can be inhibited by pepstatin A. Proc Natl Acad Sci U S A. 1988 Sep;85 (18) :6612-6.