Amicoumacin B

Amicoumacin B can be produced by actinomycete, strain 04-5195T.. Amicoumacin B increases the expression of bone morphogenetic protein 2 (BMP-2) . Amicoumacin B has inhibitory effect against C. violaceum (MIC = 250 µg/mL) . Amicoumacin B has quorum sensing inhibitory activity, and reduces the expression of the C. violaceum operons vioA, vioB, vioD, and vioE, but increases the expression of vioC[1][2].

Product Specifications

CAS Number

[77674-99-8]

UNSPSC

12352005

Target

Bacterial; TGF-beta/Smad

Related Pathways

Anti-infection; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Infection

Smiles

O=C1C2=C(O)C=CC=C2C[C@@](O1)([H])[C@H](CC(C)C)NC([C@@H](O)[C@@H](O)[C@@H](N)CC(O)=O)=O

Molecular Formula

C20H28N2O8

Molecular Weight

424.44

References & Citations

[1]Shi WP, et al. Amicoumacins from a desert bacterium: quorum sensing inhibitor against Chromobacterium violaceum. Nat Prod Res. 2021 Dec;35 (23) :5508-5512.|[2]Sun W, et al. Nocardia jinanensis sp. nov., an amicoumacin B-producing actinomycete. Int J Syst Evol Microbiol. 2009 Feb;59 (Pt 2) :417-20.