5,7,3',4'-Tetramethoxyflavone

5,7,3',4'-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling[1].

Product Specifications

CAS Number

[855-97-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Fungal; Parasite

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Concentration

10mM

Purity

99.15

Solubility

DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C1C(OC)=CC(OC)=C3

Molecular Formula

C19H18O6

Molecular Weight

342.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Wu L, et al. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling in vivo and in vitro. Biochem Biophys Res Commun. 2014 Sep 26;452 (3) :682-8.|[2]Wu L, et al. 5,7,3',4'-Tetramethoxyflavone protects chondrocytes from ER stress-induced apoptosis through regulation of the IRE1α pathway. Connect Tissue Res. 2018 Mar;59 (2) :157-166. |[3]Wei G, et al. Absolute bioavailability, pharmacokinetics and excretion of 5,7,30 ,40 -tetramethoxyflavone