Cyclothiazomycin

Cyclothiazomycin selectively inhibits renin activity and does not inhibit pepsin, aspartic acid, serine, mercaptan protease and metalloproteinases. Cyclothiazomycin has weak antifungal activity[1].

Product Specifications

CAS Number

[133352-26-8]

UNSPSC

12352005

Target

Fungal

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

C=C(NC([C@@H]1CSC(C2=CSC(C3=CC=C(C(N[C@H](C4=N[C@H](C(N/C(C(N[C@@](C)(SC5)C6=O)=O)=C\C)=O)CS4)CC(N)=O)=O)C([C@H](NC([C@@H]7CCCN7C(/C(NC(CNC([C@@H](N6)[C@@H](C)O)=O)=O)=C/C)=O)=O)C)=N3)=N2)=N1)=O)C8=NC(C9=NC(C%10=N[C@H](C(N[C@@H]5C(O)=O)=O)CS%10)=CS9)=CS8

Molecular Formula

C59H64N18O14S7

Molecular Weight

1473.71

References & Citations

[1]M Aoki, et al. Cyclothiazomycin, a novel polythiazole-containing peptide with renin inhibitory activity. Taxonomy, fermentation, isolation and physico-chemical characterization. J Antibiot (Tokyo) . 1991 Jun;44 (6) :582-8.