Hypocrellin A (Standard)

Hypocrellin A (Standard) is the analytical standard of Hypocrellin A. This product is intended for research and analytical applications. Hypocrellin A is a PKC inhibitor that exerts antidiabetic activity by reversing the effects of high glucose on endothelin (ET-1) expression. Hypocrellin A is also a photosensitizer for photodynamic therapy (PDT) with anticancer, antibacterial and antiviral activities, especially against human immunodeficiency virus (HIV) . In addition, Hypocrellin-A also possesses anti-Leishmania activity (IC50=0.27 μg/ml) [1][2][3][4][5][6][7][8][9].

Product Specifications

CAS Number

[77029-83-5]

UNSPSC

12352005

Target

Apoptosis; Bacterial; Bcl-2 Family; HIV; Parasite; PKC; Reference Standards; VEGFR; VSV

Related Pathways

Anti-infection; Apoptosis; Epigenetics; Others; Protein Tyrosine Kinase/RTK; TGF-beta/Smad

Field of Research

Cancer; Infection; Metabolic Disease

Smiles

COC(C1=O)=C2C3=C(C1=C(C=C4OC)O)C4=C(C(OC)=CC(O)=C56)C5=C3C(CC(C)(O)C2C(C)=O)=C(OC)C6=O

Molecular Formula

C30H26O10

Molecular Weight

546.52

References & Citations

[1]Dang L, et al. Effects of hypocrellin A on expression of vascular endothelial growth factor and endothelin-1 in human umbilical endothelial cells. Am J Chin Med. 2007;35 (4) :713-23.|[2]Ma YJ, et al. Enhanced Production of Hypocrellin A in Submerged Cultures of Shiraia bambusicola by Red Light. Photochem Photobiol. 2019 May;95 (3) :812-822.|[3]Fehr MJ, et al. Roles of oxygen and photoinduced acidification in the light-dependent antiviral activity of hypocrellin A. Biochemistry. 1995 Dec 5;34 (48) :15845-8.|[4]Ma G, et al. Antimicrobial and antileishmanial activities of hypocrellins A and B. Antimicrob Agents Chemother. 2004 Nov;48 (11) :4450-2.|[5]Hirayama, et al. "Photoinactivation of virus infectivity by hypocrellin A." Photochemistry and photobiology 66.5 (1997) : 697-700.|[6]Deininger, et al. "Release of regulators of angiogenesis following Hypocrellin-A and-B photodynamic therapy of human brain tumor cells." Biochemical and Biophysical Research Communications 298.4 (2002) : 520-530.|[7]Yujie, et al. "Photodynamic antimicrobial activity of hypocrellin A." Journal of Photochemistry and Photobiology B: Biology 103.1 (2011) : 29-34.|[8]Yang, et al. "Hypocrellin A exerts antitumor effects by inhibiting the FGFR1 signaling pathway in non-small cell lung cancer." Phytomedicine 97 (2022) : 153924.|[9]Guo, et al. "Evaluation of hypocrellin A-loaded lipase sensitive polymer micelles for intervening methicillin-resistant Staphylococcus Aureus antibiotic-resistant bacterial infection." Materials Science and Engineering: C 106 (2020) : 110230.