Pyrrocidine B

Pyrrocidine B (Compound 6), an alkaloid, is a microbial secondary metabolite. Pyrrocidine B can be isolated from the endophytic fungus Neonectria ramulariae Wollenw KS-246. Pyrrocidine B has significant cytotoxicity against leukemia cells (IC50 of 4.6 μM for HL60 cells) with a weak Prolyl oligopeptidase (POP) inhibitory activity[1].

Product Specifications

CAS Number

[428439-25-2]

UNSPSC

12352005

Target

Endogenous Metabolite; Prolyl Endopeptidase (PREP)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

C[C@]1(C[C@@H]2C)[C@](C(C)=C3)([H])[C@]([C@](C([C@](C(N4)=O)([H])C[C@@]4(C5)O)=O)([H])[C@@H]3C=C)([H])[C@@](OC6=CC=C5C=C6)([H])[C@]1([H])[C@H](C2)C

Molecular Formula

C31H39NO4

Molecular Weight

489.65

References & Citations

[1]Shiono Y, et al. A dimeric pyrrocidine from Neonectria ramulariae is an inhibitor of prolyl oligopeptidase[J]. Phytochemistry Letters, 2012, 5 (1) : 91-95.