Illudin B
Illudin B is a DNA-targeting cytotoxin that forms interstrand DNA crosslinks via covalent binding, disrupting DNA replication and transcription. Illudin B induces cell cycle arrest and apoptosis, showing toxicity against multiple tumor cells (e.g., leukemia, breast, lung cancer) [1].
Product Specifications
CAS Number
[134857-03-7]
UNSPSC
12352211
Target
Apoptosis; DNA/RNA Synthesis
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
C[C@]1(C2(CC2)[C@@](O)(C(C3=C1[C@H](C(C)([C@H]3O)C)O)=O)C)O
Molecular Formula
C15H22O5
Molecular Weight
282.33
References & Citations
[1]Burgess ML, et al. Characterization of new illudanes, illudins F, G, and H from the basidiomycete omphalotus nidiformis. J Nat Prod. 1999 Nov;62 (11) :1542-4.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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