Berkeleyamide C
Berkeleyamide C is a selective matrix metalloproteinase-3 (MMP-3) and caspase-1 inhibitor. Berkeleyamide C blocks MMP-3-mediated tumor cell invasion and metastasis, as well as the abnormal activation of inflammation and apoptosis related to caspase-1. Berkeleyamide C is promising for research of cancers and inflammation-related diseases[1].
Product Specifications
CAS Number
[1019854-23-9]
UNSPSC
12352005
Target
Caspase; MMP
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Smiles
CC(O[C@@H](C1=CC=CC=C1)C(N(C=C2C(NC(CC(C)C)=O)=O)CCO)=CC2=O)=O
Molecular Formula
C22H26N2O6
Molecular Weight
414.45
References & Citations
[1]Stierle AA, et al. The berkeleyamides, amides from the acid lake fungus Penicillum rubrum. J Nat Prod. 2008 May;71 (5) :856-60.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase 1; MMP-3
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