2-ACC
2-ACC (2-α-Carboxy cholestanol) is a cholestanol, is a mutant Sonic Hedgehog protein D46A activator with an EC50 of ～5 μM.
Product Specifications
CAS Number
[3091880-01-9]
Product Name Alternative
2-α-Carboxy cholestanol
UNSPSC
12352100
Target
Hedgehog
Related Pathways
Stem Cell/Wnt
Field of Research
Metabolic Disease
Smiles
C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H]([C@@H](C2)C(O)=O)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C
Molecular Formula
C28H48O3
Molecular Weight
432.68
References & Citations
[1]Ciulla DA, et al. A cell-based bioluminescence reporter assay of human Sonic Hedgehog protein autoprocessing to identify inhibitors and activators. J Biol Chem. 2022 Dec;298 (12) :102705.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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