FP-20 (sodium)

FP-20 sodium, a selective TLR4 agonist, is a vaccine adjuvant. FP-20 sodium induces MAPK- and NLRP3-dependent inflammasome activation. FP20 shows no toxicity in mouse vaccination experiments with OVA antigen and induces IgG production[1].

Product Specifications

CAS Number

[3056013-47-6]

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

CCCCCCCCCCCC(N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1OC(CCCCCCCCCCC)=O)CO)OP(O)(O[Na])=O)OC(CCCCCCCCCCC)=O)=O

Molecular Formula

C42H79NNaO11P

Molecular Weight

828.04

References & Citations

[1]Alessio Romerio, et al. New Glucosamine-Based TLR4 Agonists: Design, Synthesis, Mechanism of Action, and In Vivo Activity as Vaccine Adjuvants. J Med Chem. 2023 Feb 23;66 (4) :3010-3029.