VSA 1

VSA 1, a semisynthetic QS-21 (HY-101092) analog, is a saponin adjuvant. VSA 1 potentiates antigen-specific IgG1 and IgG2a immune responses in BALB/c mice, indicating a mixed Th1/Th2 immune response. VSA 1 significantly improves vaccine efficacy after primary immunization and enhances homologous protection[1].

Product Specifications

CAS Number

[2489675-55-8]

UNSPSC

12352211

Target

Drug Derivative

Related Pathways

Others

Field of Research

Infection; Inflammation/Immunology

Smiles

O[C@H]([C@@H]([C@H]([C@@H](O1)C)O[C@H]2[C@@H]([C@H]([C@@H](CO2)O)O)O)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O[C@H]4[C@@H]([C@H]([C@@H](CO4)O)O)O)O)[C@@H]1O[C@H]([C@H]([C@H]([C@H](O5)C)O)O)[C@@H]5OC([C@]67[C@](CC(C)(CC7)C)([H])C8=CC[C@@]([C@@]9([C@@]([C@@](C)([C@H](CC9)O[C@H]%10[C@@H]([C@H]([C@@H]([C@H](O%10)C(NCCCCCCCCCCCC)=O)O)O[C@H]%11[C@@H]([C@@H]([C@H]([C@@H](O%11)C)O)O)O)O[C@@H]%12O[C@@H]([C@@H]([C@@H]([C@H]%12O)O)O)CO)C=O)([H])CC%13)C)([H])[C@]%13(C)[C@@]8(CC6)C)=O

Molecular Formula

C88H145NO39

Molecular Weight

1841.08

References & Citations

[1]Bhatnagar N, et al. Adjuvant Effects of a New Saponin Analog VSA-1 on Enhancing Homologous and Heterosubtypic Protection by Influenza Virus Vaccination. Vaccines (Basel) . 2022 Aug 24;10 (9) :1383.