Tiancimycin A

Tiancimycin A (TNM A) is an anticancer agent. Tiancimycin A induces rapid DNA damage, cell cycle arrest, and apoptosis. Tiancimycin A can be isolated from Streptomyces sp. CB03234[1][2].

Product Specifications

CAS Number

[1965327-09-6]

Product Name Alternative

TNM A

UNSPSC

12352005

Target

Apoptosis

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

C[C@H]([C@@]12[C@]3(O2)C4=CC(O)=C(C(C5=CC=C6OC)=O)C(C(C5=C6O)=O)=C4N[C@@]1([H])C#CC=CC#C[C@H]3O)O

Molecular Formula

C27H19NO8

Molecular Weight

485.44

References & Citations

[1]Feng X, et al. Liposome-Encapsulated Tiancimycin A Is Active against Melanoma and Metastatic Breast Tumors: The Effect of cRGD Modification of the Liposomal Carrier and Tiancimycin A Dose on Drug Activity and Toxicity. Mol Pharm. 2022 Apr 4;19 (4) :1078-1090.|[2]Liu L, et al. Ribosome engineering and fermentation optimization leads to overproduction of tiancimycin A, a new enediyne natural product from Streptomyces sp. CB03234. J Ind Microbiol Biotechnol. 2018 Mar;45 (3) :141-151.