Azafrin

Azafrin, a carotenoid, is one of the most abundant active ingredients in C. grandiflora. Azafrin increases HO-1, NQO1, and Nrf2 expression. Azafrin shows cardioprotective effect against myocardial injury via activation of the Nrf2-ARE pathway. Azafrin can be used for research of cardiovascular diseases[1].

Product Specifications

CAS Number

[507-61-9]

UNSPSC

12352211

Target

Heme Oxygenase (HO) ; Keap1-Nrf2

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Smiles

OC(/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/[C@]1(C(C)(CCC[C@]1(O)C)C)O)=O

Molecular Formula

C27H38O4

Molecular Weight

426.59

References & Citations

[1]Yang S, et al. Cardioprotective role of azafrin in against myocardial injury in rats via activation of the Nrf2-ARE pathway. Phytomedicine. 2018 Aug 1;47:12-22.