Triptriolide

Triptriolide inhibits Puromycin aminonucleoside PAN (HY-15695) -induced apoptosis in mouse podocytes through regulation of Bcl-2 family proteins and inhibition of Caspase-3. Triptriolide promotes the cell survival, protects and restores the podocyte function through activation of TAK1-NF-κB signaling pathway and upregulation of podocin[1].

Product Specifications

CAS Number

[137131-18-1]

UNSPSC

12352005

Target

Apoptosis; MAP3K; NF-κB

Related Pathways

Apoptosis; MAPK/ERK Pathway; NF-κB

Field of Research

Others

Smiles

C[C@@]12[C@@]34[C@]5([C@@H]([C@@](O)([C@@H]([C@]3([H])O4)O)C(C)C)O)[C@@](C[C@@]1([H])C6=C(C(OC6)=O)CC2)([H])O5

Molecular Formula

C20H26O7

Molecular Weight

378.42

References & Citations

[1]Yang YQ, et al., Dual-function of triptriolide in podocytes injury: inhibiting of apoptosis and restoring of survival. Biomed Pharmacother. 2019 Jan;109:1932-1939.