Syringolin A
Syringolin A is a plant elicitor that can be produced by the plant pathogen Pseudomonas syringae pv. syringae. Syringolin A exhibits anti-proliferative activity against a variety of cancer cells (IC50 for SK-N-SH, LAN-1, SKOV3 is 20-25 µM), induces apoptosis in SK-N-SH through upregulation of p53 expression and downregulation of Akt/PKB proteins[1].
Product Specifications
CAS Number
[212115-96-3]
UNSPSC
12352211
Target
Akt; Apoptosis; MDM-2/p53
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
CC(C)[C@@H](C(O)=O)NC(N[C@H](C(N[C@@H]1C(N[C@@H](C(C)C)/C=C/C(NCC/C=C/1)=O)=O)=O)C(C)C)=O
Molecular Formula
C24H39N5O6
Molecular Weight
493.60
References & Citations
[1]Coleman CS, et al., Syringolin A, a new plant elicitor from the phytopathogenic bacterium Pseudomonas syringae pv. syringae, inhibits the proliferation of neuroblastoma and ovarian cancer cells and induces apoptosis. Cell Prolif. 2006 Dec;39 (6) :599-609.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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