Ovalitenone

Ovalitenone is a flavonoid compound that can be isolated from the plant Millettia peguensis. It shows no cytotoxic effects on lung cancer H460 and A549 cells, but it significantly inhibits anchorage-independent growth, CSC-like phenotypes, colony formation, and the migration and invasion capabilities of cancer cells. Ovalitenone can significantly reduce the levels of N-cadherin, snail, and slug, while increasing E-cadherin, thus inhibiting the EMT pathway. Additionally, Ovalitenone suppresses the signaling pathways regulated by focal adhesion kinase (FAK), ATP-dependent tyrosine kinase (AKT), mammalian target of rapamycin (mTOR), and cell division cycle 42 (Cdc42) [1][2].

Product Specifications

CAS Number

[64280-22-4]

UNSPSC

12352005

Target

Akt; FAK; mTOR

Related Pathways

PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(CC(C1=CC=C2OC=CC2=C1OC)=O)C3=CC=C4OCOC4=C3

Molecular Formula

C19H14O6

Molecular Weight

338.31

References & Citations

[1]Kittipong Sanookpan, et al. Ovalitenone Inhibits the Migration of Lung Cancer Cells via the Suppression of AKT/mTOR and Epithelial-to-Mesenchymal Transition. Molecules. 2021, 26, 638.|[2]Seru Ganapaty, et al. Flavonoids from Millettia peguensis Ali (Fabaceae) . Biochemical Systematics and Ecology 26 (1998) 125-126.