Hexacyclinol
Hexacyclinol has moderate anti-Gram-positive bacteria activity, 4-40 μg/mL can inhibit the production of oxidants by polymorphonuclear neutrophils (PMNL) stimulated by zymosan. Hexacyclinol inhibits the growth of L-930 and K 562 cells with IC50s of 1.4 μg/mL and 0.4 μg/mL, respectively, and the IC50 of HeLa cells is 10 μg/mL. Hexacyclinol also has an anti-Plasmodium effect, and its IC50 for Plasmodium falciparum is 2.4 μg/mL[1].
Product Specifications
CAS Number
[903574-41-4]
UNSPSC
12352005
Target
Bacterial; Parasite
Related Pathways
Anti-infection
Field of Research
Cancer; Infection
Smiles
COC(C)([C@@H]1[C@@]23[C@@]([C@@]4([H])C(C([C@]5([H])[C@](O5)([H])[C@@H]4O)=O)=C1)([H])[C@@]([C@@]6([H])[C@@](O6)([H])C3=O)([H])O[C@@H]2/C=C(C)\C)C
Molecular Formula
C23H28O7
Molecular Weight
416.46
References & Citations
[1]David M Pinkerton, et al. (+) -hexacyclinol. Acta Crystallogr Sect E Struct Rep Online. 2010 Jan 13;66 (Pt 2) :o342-3.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
