Xanthofulvin

Xanthofulvin is a semaphorin inhibitor with an IC50 of 0.09 μg/mL[1].

Product Specifications

CAS Number

[151466-15-8]

Product Name Alternative

SM-216289

UNSPSC

12352211

Target

Others

Related Pathways

Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C(C(C(O)=C(C=C1OC2=C3C=C(C(C)=C2C(C)=O)/C(O)=C4C(C5=C(C(O)=O)C(O)=C(O)C=C5OC/4)=O)O)=C1C3=O)O

Molecular Formula

C28H18O14

Molecular Weight

578.43

References & Citations

[1]Kazuo Kumagai, et al. Xanthofulvin, a novel semaphorin inhibitor produced by a strain of Penicillium. J Antibiot (Tokyo) . 2003 Jul;56 (7) :610-6.|[2]Maione F, Molla F, Meda C, et al. Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models. J Clin Invest. 2009;119 (11) :3356-3372. |[3]Kikuchi K, Kishino A, Konishi O, et al. In vitro and in vivo characterization of a novel semaphorin 3A inhibitor, SM-216289 or xanthofulvin. J Biol Chem. 2003;278 (44) :42985-42991.