Pyripyropene B

Pyripyropene B is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor found in the fungus Aspergillus fumigatus FO 1289. Pyripyropene B inhibits acyl-CoA: cholesterol acyltransferase with an IC50 of 117 nM[1].

Product Specifications

CAS Number

[151519-44-7]

UNSPSC

12352005

Target

Acyltransferase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

C[C@@]12[C@]3([H])[C@@]([C@H](C[C@@]1([H])[C@@](C)([C@H](CC2)OC(C)=O)COC(CC)=O)OC(C)=O)(OC4=C(C(OC(C5=CN=CC=C5)=C4)=O)[C@@H]3O)C

Molecular Formula

C32H39NO10

Molecular Weight

597.65

References & Citations

[1]Y K Kim, et al. Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D. J Antibiot (Tokyo) . 1994 Feb;47 (2) :154-62.