Madindoline B
Madindoline B is an IL-6 inhibitor. Madindoline B inhibits IL-6-dependent MH-60 cells and has no inhibitory effect on IL-6-independent MH-60 cells. In the presence of 0.1 U/mL IL-6, it inhibits IL-6-dependent MH-60 cells with an IC50 of 30 μM. Madindoline B has no antimicrobial effect[1].
Product Specifications
CAS Number
[184877-65-4]
UNSPSC
12352211
Target
Interleukin Related
Related Pathways
Immunology/Inflammation
Field of Research
Infection
Smiles
O[C@@](C1=CC=CC=C12)(CCO3)[C@@]3([H])N2C[C@@]4(C(C(CCCC)=C(C4=O)C)=O)C
Molecular Formula
C22H27NO4
Molecular Weight
369.45
References & Citations
[1]Lifeng Wan, et al. Synthesis of (+) -madindoline A and (+) -madindoline B. Org Lett. 2007 Feb 15;9 (4) :647-50.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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