Calcitroic acid

Calcitroic acid is a vitamin D receptor (VDR) agonist that can activate VDR-mediated transcription. Calcitroic acid is the main metabolite of 1,25-dihydroxyvitamin D3, with the highest concentrations found in the liver and mucosa of mice, and it has metabolic stability and very low toxicity[1][2].

Product Specifications

CAS Number

[71204-89-2]

UNSPSC

12352211

Target

Drug Metabolite; VD/VDR

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer; Metabolic Disease

Purity

85.0

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC(O)=O)([H])/C(CCC1)=C/C=C3C([C@H](C[C@@H](C\3)O)O)=C

Molecular Formula

C23H34O4

Molecular Weight

374.51

References & Citations

[1]Kelly A Teske, et al. Synthesis and Evaluation of Vitamin D Receptor-Mediated Activities of Cholesterol and Vitamin D Metabolites. Eur J Med Chem. 2016 Jan 6;109:238–246. |[2]R P Esvelt, et al. Calcitroic acid: biological activity and tissue distribution studies. Arch Biochem Biophys. 1981 Feb;206 (2) :403-13.