M-H2S

M-H2S is an endoplasmic reticulum-targeted ratio-type near-infrared fluorescent probe (Ex/Em : 480 nm/560 nm) specifically designed for the detection of hydrogen sulfide (H2S) in living cells and zebrafish. M-H2S exhibits detection limit for H2S of 39.1 nM, and the fluorescence intensity ratio (F₆₅₀/F₅₆₀) within the range of 0-40 μM shows a linear relationship with the H2S concentration. M-H2S responds best under pH = 7.2 (the normal physiological pH of the endoplasmic reticulum) conditions, making it suitable for the detection of the microenvironment of the endoplasmic reticulum. M-H2S can be used to study the role of H2S in endoplasmic reticulum function, stress response, and related diseases[1].

Product Specifications

CAS Number

[2522921-17-9]

UNSPSC

12352005

Target

Fluorescent Dye

Related Pathways

Others

Field of Research

Others

Smiles

CC1(CC(/C=C/C2=CC=C(C=C2)OC(C3=CC=CC=C3C=O)=O)=C/C(C1)=C(C#N)\C#N)C

Molecular Formula

C27H22N2O3

Molecular Weight

422.48

References & Citations

[1]Shu W, et al. An Endoplasmic Reticulum-Targeted Ratiometric Fluorescent Probe for the Sensing of Hydrogen Sulfide in Living Cells and Zebrafish. Anal Chem. 2020 Jul 21;92 (14) :9982-9988.