Rotenone-d3

Rotenone-d3 is the deuterium labeled Rotenone (HY-B1756) . Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

Product Specifications

CAS Number

[82092-80-6]

UNSPSC

12352005

Target

Apoptosis; Autophagy; Isotope-Labeled Compounds; Mitochondrial Metabolism

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Neurological Disease

Smiles

O=C1[C@]2([H])[C@](COC3=CC(OC)=C(OC([2H])([2H])[2H])C=C32)([H])OC4=C5C(O[C@@H](C(C)=C)C5)=CC=C14

Molecular Formula

C23H19D3O6

Molecular Weight

397.44

References & Citations

[1]Khadrawy YA, et al. Cerebellar neurochemical and histopathological changes in rat model of Parkinson's disease induced by intrastriatal injection of rotenone. Gen Physiol Biophys. 2016 Nov 30.|[2]Guan Q, et al. RNA-Seq Expression Analysis of Enteric Neuron Cells with Rotenone Treatment and Prediction of Regulated Pathways. Neurochem Res. 2016 Nov 30.|[3]Kishore Kumar SN, et al. Morinda citrifolia mitigates rotenone-induced striatal neuronal loss in male Sprague-Dawley rats by preventing mitochondrial pathway of intrinsic apoptosis. Redox Rep. 2016 Nov 24:1-12.|[4]Zhang ZN, et al. Subcutaneous rotenone rat model of Parkinson's disease: dose exploration study. Brain Res. 2016 Nov 19. pii: S0006-8993 (16) 30776-4.|[5]Li N, et al. Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J Biol Chem. 2003 Mar 7;278 (10) :8516-25.