Nisoxetine (Standard)

Nisoxetine (Standard) is the analytical standard of Nisoxetine. This product is intended for research and analytical applications. Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels[1][2][3].

Product Specifications

CAS Number

[53179-07-0]

UNSPSC

12352100

Target

Monoamine Transporter; Reference Standards; Sodium Channel

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Neurological Disease

Smiles

CNCCC(OC1=CC=CC=C1OC)C2=CC=CC=C2

Molecular Formula

C17H21NO2

Molecular Weight

271.35

References & Citations

[1]Béïque JC, et, al. Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol. 1998 May 15; 349 (1) : 129-32. |[2]Cheetham SC, et, al. [3H]nisoxetine-a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology. 1996 Jan; 35 (1) : 63-70. |[3]Leung YM, et, al. Nisoxetine blocks sodium currents and elicits spinal anesthesia in rats. Pharmacol Rep. 2013; 65 (2) : 350-7. |[4]Bello NT, et al. High-fat diet-induced alterations in the feeding suppression of low-dose nisoxetine, a selective norepinephrine reuptake inhibitor. J Obes. 2013;2013:457047.