Efaroxan
Efaroxan is a potent, selective and orally active α2-adrenoceptor antagonist, with antidiabetic activity. Efaroxan is a selective I1-Imidazoline receptor antagonist. Efaroxan can be used for the research of cardiovascular disease[1][2][3].
Product Specifications
CAS Number
[89197-32-0]
UNSPSC
12352005
Target
Adrenergic Receptor; Imidazoline Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cardiovascular Disease; Metabolic Disease
Smiles
CCC1(C2=NCCN2)OC3=CC=CC=C3C1
Molecular Formula
C13H16N2O
Molecular Weight
216.28
References & Citations
[1]Berridge TL, et al. Selectivity profile of the alpha 2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin levels in the rat. Eur J Pharmacol. 1992 Mar 24;213 (2) :205-12. |[2]A O Abdel-Zaher, et al. The potential antidiabetic activity of some alpha-2 adrenoceptor antagonists. Pharmacol Res. 2001 Nov;44 (5) :397-409.|[3]T L Berridge, et al. Comparison of the effects of efaroxan and glibenclamide on plasma glucose and insulin levels in rats. Eur J Pharmacol. 1992 Mar 24;213 (2) :213-8.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B1416/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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