Olsalazine (Standard)

Olsalazine (Standard) is an orally active prodrug of 5-ASA (HY-15027) . Olsalazine (Standard) can inhibit cells proliferation and induce apoptosis. Olsalazine (Standard) can reduce DAI and MPO activity and inhibit inflammatory cytokines levels. Olsalazine (Standard) can be used for the researches of cancer, inflammation and metabolic disease, such as colorectal cancer, inflammatory bowel disease (IBD) and hyperuricemic[1][2][3][4].

Product Specifications

CAS Number

[15722-48-2]

UNSPSC

12352005

Target

Apoptosis; Reference Standards

Related Pathways

Apoptosis; Others

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Smiles

O=C(O)C1=C(O)C=CC(/N=N/C2=CC(C(O)=O)=C(O)C=C2)=C1

Molecular Formula

C14H10N2O6

Molecular Weight

302.24

References & Citations

[1]Brown WA, et al. 5-aminosalicyclic acid and olsalazine inhibit tumor growth in a rodent model of colorectal cancer. Dig Dis Sci. 2000 Aug;45 (8) :1578-84.|[2]Thapa D, et al. Cannabidiol Enhances the Therapeutic Efficacy of Olsalazine and Cyclosporine in a Murine Model of Colitis. Int J Mol Sci. 2025 Aug 16;26 (16) :7913.|[3]Niu Y, et al. Olsalazine Sodium Increases Renal Urate Excretion by Modulating Urate Transporters in Hyperuricemic Animals. Biol Pharm Bull. 2020 Nov 1;43 (11) :1653-1659.|[4]Itoh S, et al. Olsalazine inhibits cell proliferation and DNA methylation in canine lymphoid tumor cell lines. Pol J Vet Sci. 2021 Dec;24 (4) :515-523.