Forasartan
Forasartan is an nonpeptide angiotensin AT1 receptor antagonist with an IC50 of 2.9 nM. Forasartan is also an anti-hypertension agent. Forasartan significantly inhibits preganglionic stimulation in a dose-dependent manner in vivo. Forasartan can inhibit the heart rate increase induced by angiotensin II[1][2][3].
Product Specifications
CAS Number
[145216-43-9]
Product Name Alternative
SC-52458
UNSPSC
12352005
Target
Angiotensin Receptor
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
CCCCC1=NC(CCCC)=NN1CC2=CN=C(C3=CC=CC=C3C4=NNN=N4)C=C2
Molecular Formula
C23H28N8
Molecular Weight
416.52
References & Citations
[1]Tokunaga, R., et al., (2001) . Possible involvement of calcium-calmodulin pathways in the positive chronotropic response to angiotensin II on the canine cardiac sympathetic ganglia. Japanese journal of pharmacology, 86 (4), 381-389.|[2]Gul, F., Parvaiz, N., & Azam, S. S. (2023) . Deciphering the relational dynamics of AF-2 domain of PAN PPAR through drug repurposing and comparative simulations. PloS one, 18 (3), e0283743.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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