Dronedarone-d6

Dronedarone-d6 (SR 33589-d6) is deuterium labeled Dronedarone. Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4[1].

Product Specifications

CAS Number

[1132693-87-8]

Product Name Alternative

SR 33589-d6

UNSPSC

12352211

Target

Adrenergic Receptor; Autophagy; Calcium Channel; Cytochrome P450; Isotope-Labeled Compounds; mAChR; Sodium Channel

Related Pathways

Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

CS(=O)(NC1=CC=C(OC(CCCC)=C2C(C3=CC=C(OC([2H])([2H])C([2H])([2H])C([2H])([2H])N(CCCC)CCCC)C=C3)=O)C2=C1)=O

Molecular Formula

C31H38D6N2O5S

Molecular Weight

562.79

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Chinmay Patel, et al. Dronedarone. Circulation. 2009 Aug 18;120 (7) :636-44.|[3]Katarzyna M Sawicka, et al. Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice. J Neural Transm (Vienna) . 2019 Feb;126 (2) :115-122.