Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

AT9283 (Standard)

AT9283 (Standard) is the analytical standard of AT9283. This product is intended for research and analytical applications. AT9283 is a multi-targeted kinase inhibitor with potent activity against Aurora A/B, JAK2/3, Abl (T315I) and Flt3 (IC50s ranging from 1 to 30 nM) . AT9283 inhibits growth and survival of multiple solid tumors in vitro and in vivo[1][2].

Product Specifications

CAS Number

[896466-04-9]

UNSPSC

12352100

Target

Apoptosis; Aurora Kinase; Autophagy; Bcr-Abl; FLT3; JAK; Reference Standards

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer

Smiles

O=C(NC1CC1)NC2=CNN=C2C3=NC4=CC=C(C=C4N3)CN5CCOCC5

Molecular Formula

C19H23N7O2

Molecular Weight

381.43

References & Citations

[1]Howard S, et al. Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity. Journal of Medicinal Chemistry (2009), 52 (2), 379-388.|[2]Qi W, et al. AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B-cell lymphomas. Int J Cancer. 2012 Jun 15;130 (12) :2997-3005.|[3]Santo L, et al. Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomide. Clin Cancer Res. 2011 May 15;17 (10) :3259-71

Shipping Conditions

Room temperature

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-50514R/

Scientific Category

Reference Standards

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Rabbit anti-Acinetobacter calcoaceticus PQQB Polyclonal Antibody
MBS7162344 Inquire

Rabbit anti-Acinetobacter calcoaceticus PQQB Polyclonal Antibody

Ask
View Details
Ddx31 Mouse shRNA Plasmid (Locus ID 227674)
TR511714 1 Kit

Ddx31 Mouse shRNA Plasmid (Locus ID 227674)

Ask
View Details
Human Defensin Alpha 3, Neutrophil Specific (DEFa3) Antibody Pair Kit (with Standard)
MBS2090329-01 5x 96 Tests

Human Defensin Alpha 3, Neutrophil Specific (DEFa3) Antibody Pair Kit (with Standard)

Ask
View Details
Human Defensin Alpha 3, Neutrophil Specific (DEFa3) Antibody Pair Kit (with Standard)
MBS2090329-02 5x 96 Tests + MBS2090685 (Ab Pairs Support Pack 1,5x 96 Tests)

Human Defensin Alpha 3, Neutrophil Specific (DEFa3) Antibody Pair Kit (with Standard)

Ask
View Details
Human Defensin Alpha 3, Neutrophil Specific (DEFa3) Antibody Pair Kit (with Standard)
MBS2090329-03 10x 96 Tests

Human Defensin Alpha 3, Neutrophil Specific (DEFa3) Antibody Pair Kit (with Standard)

Ask
View Details
Human Defensin Alpha 3, Neutrophil Specific (DEFa3) Antibody Pair Kit (with Standard)
MBS2090329-04 10x 96 Tests + MBS2090685 (Ab Pairs Support Pack 1, 10x 96 Tests)

Human Defensin Alpha 3, Neutrophil Specific (DEFa3) Antibody Pair Kit (with Standard)

Ask
View Details