PDGFR-IN-2

PDGFR-IN-2 (Compound 16C) is a 4-phenoxyquinoline derivative. PDGFR-IN-2 is a platelet-derived growth factor receptor (PDGFr) inhibitor (IC50: 0.20 μM) . PDGFR-IN-2 inhibits the activity of PDGFr tyrosine kinase[1].

Product Specifications

CAS Number

[190728-25-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PDGFR

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Purity

99.97

Solubility

DMSO : 9.09 mg/mL (ultrasonic; warming; adjust pH to 2 with 1 M HCL; heat to 60°C)

Smiles

NC1=CC=C(OC2=CC=NC3=CC(OC)=C(OC)C=C23)C=C1

Molecular Formula

C17H16N2O3

Molecular Weight

296.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Kubo K, et al. Synthesis and structure-activity relationship for new series of 4-phenoxyquinoline derivatives as specific inhibitors of platelet-derived growth factor receptor tyrosine kinase. Bioorg Med Chem. 2003 Nov 17;11 (23) :5117-33.