5-CNAC

5-CNAC is an orally active enhancer of absorption, with no pharmacological activity on its own. 5-CNAC can significantly enhance the absorption efficiency of the drug (such as salmon calcitonin) when administered together with it in the gastrointestinal tract. 5-CNAC binds reversibly and non-covalently to peptide drugs, protecting them from degradation by gastrointestinal enzymes, increasing their lipid solubility, promoting passive transcellular absorption, and not damaging the integrity of the intestinal epithelium. 5-CNAC can be used in the research of adjuvants for orally administered peptide agents[1][2].

Product Specifications

CAS Number

[204852-67-5]

UNSPSC

12352005

Target

Others

Related Pathways

Others

Field of Research

Others

Purity

99.49

Smiles

O=C(O)CCCCCCCNC(C1=CC(Cl)=CC=C1O)=O

Molecular Formula

C15H20ClNO4

Molecular Weight

313.78

References & Citations

[1]Hamdy RC, Daley DN. Oral calcitonin. Int J Womens Health. 2012;4:471-9.|[2]Gschwind HP, et al. Metabolism and disposition of the oral absorption enhancer 14C-radiolabeled 8- (N-2-hydroxy-5-chlorobenzoyl) -amino-caprylic acid (5-CNAC) in healthy postmenopausal women and supplementary investigations in vitro. Eur J Pharm Sci. 2012 Aug 30;47 (1) :44-55.