M7GTP

7-Methyl-guanosine-5'-triphosphate (m7GTP) is a guanosine 5'-phosphate. 7-Methyl-guanosine-5'-triphosphate phosphorothioate analog is a potent cap-dependent translation inhibitor[1].

Product Specifications

CAS Number

[26554-26-7]

Product Name Alternative

7-Methyl-guanosine-5'-triphosphate

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Metabolic Disease

Solubility

10 mM in DMSO

Smiles

O=[P](O[P](O[P](O)(O)=O)(O)=O)([O-])OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(N)=NC3=O)=C3[N+](C)=C2)O1

Molecular Formula

C11H18N5O14P3

Molecular Weight

537.21

References & Citations

[1]Kowalska J, et al. Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation. Bioorg Med Chem Lett. 2009 Apr 1;19 (7) :1921-5.