GR-4991W93

GR-4991W93 is an orally active partial agonist against 5HT1B/1D receptor, with pIC50 values of 6.95 and 7.80 against 5HT1B and 5HT1D, respectively. GR-4991W93 demonstrates potent inhibition of electrically evoked plasma extravasation in the guinea pig. GR-4991W93 can be used for migraine research[1].

Product Specifications

CAS Number

[171549-56-7]

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

CN(C)[C@H](C1)C[C@@H]1C2=CNC3=CC=C(C[C@@H]4NC(OC4)=O)C=C32

Molecular Formula

C18H23N3O2

Molecular Weight

313.39

References & Citations

[1]Jandu KS, et al. Discovery of 4-[3- (trans-3-dimethylaminocyclobutyl) -1H-indol-5-ylmethyl]- (4S) -oxazolidin-2-one (4991W93), a 5HT (1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation. J Med Chem. 2001 Mar 1;44 (5) :681-93.