ZD-2767
ZD-2767 is an antibody-directed enzyme prodrug therapy (ADEPT) agent. ZD-2767 is composed of the prodrug ZD2767P, carboxypeptidase G2 (CPG2), and the active drug ZD2767D. ZD-2767 achieves tumor-targeted drug delivery through an innovative ADEPT strategy, triggering apoptosis of cancer cells by causing irreparable DNA damage. ZD-2767 can be used for cancer research[1].
Product Specifications
CAS Number
[156079-88-8]
UNSPSC
12352005
Target
Apoptosis; DNA Alkylator/Crosslinker; DNA/RNA Synthesis
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(O)CC[C@@H](C(O)=O)NC(OC1=CC=C(N(CCI)CCI)C=C1)=O
Molecular Formula
C16H20I2N2O6
Molecular Weight
590.15
References & Citations
[1]Monks NR, et al. Induction of apoptosis by the ADEPT agent ZD2767: comparison with the classical nitrogen mustard chlorambucil and a monofunctional ZD2767 analogue. Br J Cancer. 2001 Sep 1;85 (5) :764-71.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
