SQ-33600

SQ-33600 is an HMG-CoA reductase inhibitor. SQ-33600 has cholesterol-lowering activity. SQ-33600 possesses cell-type selectivity, with much higher inhibitory activity on rat hepatocytes (IC50: 93 nM) than on human skin fibroblasts (IC50: 14200 nM) . SQ-33600 can be used in the research of diseases such as hypercholesterolemia[1][2].

Product Specifications

CAS Number

[133983-25-2]

UNSPSC

12352005

Target

HMG-CoA Reductase (HMGCR)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Endocrinology; Metabolic Disease

Smiles

O=C(C[C@@H](CP(C#CC(N1C2=CC=C(C=C2)F)=C(C3=C1C=CC=C3)C(C)C)(O[Na])=O)O)O[Na]

Molecular Formula

C23H21FNNa2O5P

Molecular Weight

487.37

References & Citations

[1]Wang-Iverson D, et al. Determination of SQ 33,600, a phosphinic acid containing HMG CoA reductase inhibitor, in human serum by high-performance liquid chromatography combined with ionspray mass spectrometry. Biol Mass Spectrom. 1992 Apr;21 (4) :189-94.|[2]Jagoda E, et al. Radioimmunoassay for hydroxyphosphinyl-3-hydroxybutanoic acid (SQ 33,600), a hypocholesterolemia agent. Ther Drug Monit. 1993 Jun;15 (3) :213-9.